A Test for Early Pancreatic Cancer Detection

Avantect Pancreatic Cancer Test

Avantect Pancreatic Cancer Test

Avantect is a blood test that detects epigenomic and genomic profiles of cell-free DNA (cfDNA) associated with pancreatic cancer. Developed using cutting-edge epigenomic and genomic science as well as machine learning, it provides actionable information to help guide next steps when a cancer signal is detected.


The Avantect Pancreatic Cancer Test is specifically designed for the early detection of pancreatic cancer

Easy to use

A routine blood draw makes it easy to incorporate the Avantect test into clinical management protocols for high-risk patients

Actionable report

Clear information about whether signals are detected, with recommendations for next steps


Epigenomic changes are present in the earliest stages of pancreatic cancer,1 and 5-hydroxymethylcytosine (5hmC), a chemical modification of DNA, can be used as a targeted biomarker to identify these changes.

Using the latest epigenomic and genomic science, the Avantect test may reveal the emergence of cancer cells earlier than established methods.2,3 Its streamlined technology uses a combination of 5hmC profiling and whole-genome sequencing in a single assay to enable a deep look into cancer biology.1

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Get in touch via the form below to learn more about Avantect or to schedule a call with one of our experts. See how easy it is to use the Avantect test with your high-risk patients.

Important information

The Avantect Pancreatic Cancer Test is an early detection test. The test does not establish a diagnosis of pancreatic cancer, and results should be considered in the context of other clinical criteria. Definitive diagnosis of pancreatic cancer usually requires a series of imaging scans, blood tests, and a biopsy. Not all pancreatic cancers will be detected. Some patients with pancreatic cancer may have a “Signal not detected” result. Some patients without pancreatic cancer may have a “Signal detected” result. False-negative and false-positive results are possible. A “Signal not detected” result does not guarantee that no pancreatic cancer is present. In some cases, no result is obtained. While this is very uncommon, it may be caused by shipping delays or when there is not enough cell-free DNA for the test in the patient’s blood. If this happens, we generally ask for a repeat blood sample for testing at no extra cost.

The test was developed in the ClearNote Health CLIA-certified (CLIA# 05D2249973) and CAP-accredited (CAP# 9219174) laboratory and has not been cleared or approved by the US Food and Drug Administration (FDA).

References and notes

  1. Guler GD, Ning Y, Ku CJ, et al. Detection of early stage pancreatic cancer using 5-hydroxymethylcytosine signatures in circulating cell free DNA. Nat Commun. 2020;11:5270.
  2. Song CX, Yin S, Ma L, et al. 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages. Cell Res. 2017;27:1231–1242.
  3. ClearNote Health, data on file.